Vitreous Fluorophotometry

Photometric device detects early disease-related retinal changes and damage. Ophthalmology Times (August 1981).

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Anstadt B, Blair NP, Rusin M, Cunha-Vaz JG, Tso M. Alteration of the blood-retinal barrier by sodium iodate: kinetic vitreous fluorophotometry and horseradish peroxidase tracer studies. Exp Eye Res 35:653-662 (1982).  PubMed

Araie M, Maurice DM. The loss of fluorescein, fluorescein glucuronide, and fluorescein Isothiocyanate dextran from the vitreous by the anterior and retinal pathways. Exp Eye Res 52:27-39 (1991).  PubMed

Araie M, Sugiura Y, Minota K, Akazawa K. Effects of the encircling procedure on the aqueous flow rate in retinal detachment eyes: A fluorometric study. Br J Ophthalmol 71: 510-515 (1987).  PubMed

Archer DB, Gardiner TA, Sharma NK. The inner blood-retinal barrier in diabetes. Graefe’s Arch Clin Exp Ophthalmol 222:186-188 (1985).

Ashton N, Cunha-Vaz JG. Effect of histamine on the permeability of the ocular vessels. Arch Ophthalmol 73:211-222 (1965).  PubMed

Bahgat M, Anis HH, Peyman GA, Farahat HG, Parry GJ, Khoobehi B. Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats. Int Ophthalmol 15(5):335-41 (1991). PubMed

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Barsotti MF, Bartels SP, Kamm RD, Freddo TF. Background-protein effects on fluorophotometric data. Invest Ophthalmol Vis Sci 30:2046-2050 (1990).  PubMed

Baurmann H, Chioralia G, Seifert H. Fluorescence microscopy study of fluorescein in the posterior segment of the eye following local application of drugs. Klin Monatsbl Augenheilkd 183:32-36 (1983).  PubMed

Bellhorn RW, Korte GE. Permeability of abnormal blood-retinal barriers in rat phototoxic retinopathy: a clinicopathologic correlation study using fluorescent markers. Invest Ophthalmol Vis Sci 24:972-975 (1983).  PubMed

Bellhorn RW, Lipman DA, Confino J, Burns MS. Effect of monosodium glutamate on retinal vessels development and permeability in rats. Invest Ophthalmol Vis Sci 21:237-247 (1981).   PubMed

Bellhorn RW. Permeability of blood-ocular barriers of neonatal and adult cats to fluorescein-labeled dextrans of selected molecular sizes. Invest Ophthalmol Vis Sci 21:282-290 (1981).  PubMed

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Benitez del Castillo JM, Catillo A, Sanchez JG, Ruibal JL, Reverte F, Ibarra JM. An 18-month vitreous fluorophotometric follow-up study in juvenile diabetes. Acta Ophthalmol 71:651- (1993).  PubMed

Benitez del Castillo JM, Ruibal JL, Reverte F, Seara G, Fernandez PC, Duran S, Casado E, Garcia Sanchez G. Growth hormone suppression with oral pirenzepine in insulin-dependent diabetics. A Study by Vitreous Fluorophotometry. J Fr Ophtalmol 17:110- (1994).  PubMed

Berezovsky DE, Patel SR, McCarey BE, Edelhauser HF. In vivo ocular fluorophotometry: delivery of fluoresceinated dextrans via transscleral diffusion in rabbits. Invest Ophthalmol Vis Sci 52(10):7038-45 (2011). PubMed

Berthet P, Farine JC, Barras JP. Calcium dobesilate: pharmacological profile related to its use in diabetic retinopathy. Int J Clin Pract 53(8):631-6 (1999). PubMed

Bhattacharya M, Sadeghi A, Sarkhel S, Hagström M, Bahrpeyma S, Toropainen E, Auriola S, Urtti A. Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery. J Control Release 327:584-594 (2020). PubMed

Blair NP, Evans MA, Lesar TS, Zeimer RC. Fluorescein and fluorescein glucuronide pharmacokinetics after intravenous injection. Invest Ophthalmol Vis Sci 27:1107-1114 (1986).  PubMed

Blair NP, Feigelman MJ, Zeimer RC, Rusin MM, Rhee AJ. Vitreous fluorophotometry after cataract surgery. Invest Ophthalmol Vis Sci 26(Suppl):30 (1985). 

Blair NP, Feke GT, Morales-Stoppello J, Riva CE, Goser DG, Collas G, McMeel JW. Prolongation of the retinal mean circulation time in diabetes. Arch Ophthalmol 100:764-768 (1982).  PubMed

Blair NP, Goldberg MG, Fishman GA, Salzano T. Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Br J Ophthalmol 68:2-9 (1984).  PubMed

Blair NP, Jones CW, Rusin MM. Pathophysiology of the blood-retinal barrier in experimental diabetes: Vitreous fluorophotometry using carboxyfluorescein and fluorescein. Arch Ophthalmol 102:1810-1814 (1984).  PubMed

Blair NP, Zeimer RC, Rusin MM, Cunha-Vaz JG. Outward transport of fluorescein from the vitreous in normal human subjects. Arch Ophthalmol 101:1117-1121 (1983).  PubMed

Blanksma LJ, Kooijman AC, Siertsema JV, Roze JH. Clinical applications of fluorophotometry. Doc Ophthalmol 55:37-40 (1983).  PubMed

Bleicher SJ, Lee TY, Bernstein R, et al. Effect of blood glucose control on retinal vascular permeability in insulin-dependent diabetes mellitus. Diabetes Care 3:184-186 (1980).  PubMed

Boot JP, Van Gerven JMA, Van Best JA, Vrij L, Lemkes HHPJ, Oosterhuis JA. Blood retinal and blood aqueous barriers in diabetics by fluorophotometry. Doc Ophthalmol 71:19 (1989).   PubMed

Bordat B, Guirgis IR, Manderscheid JC. Vitreous Fluorophotometry in Diabetic Patients With No or Minimal Retinopathy. J Fr Ophthalmol 13:343- (1990).  PubMed

Bordat B, Misse P, Zaluski S, Rouault R, Mirouze J. Surveillance par vitreofluorophotometrie de diabetiques traites par pompe a insuline, avec retinopathie absente ou minime. (Vitreofluorophotometric Follow-Up of Diabetic Patients Treated by Continuous Insulin Infusion With No or Min. Retinopathy: 3 Year Results .) J Fr Ophthal 12:421-425 (1989).  PubMed

Borsje RA, Vrensen GFJM, van Best JA, Oosterhuis JA. Fluorophotometric determination of the function of the blood retinal barrier (cont) Supp Title: Abstracts from the 183rd Congress… Int Ophthalmol 13:478 (1989)

Borsje RA, Vrensin GFJM, van Best JA, Oosterhuis JA. Fluorophotometric determination of the blood retinal barrier after exposure to white light – Supp Title: Abstracts/183rd Congress… Int Ophthalmol 13:437 (1989). 

Boxrud C, Yablonski ME, Fong N, Soleymani L, Cook DJ, Jovanovic L. Diabetic retinopathy and aqueous humor production. Invest Ophthalmol Vis Sci 26(Suppl):286 (1985). 

Braude LS, Cunha-Vaz JG, Frenkel M. Vitreous fluorophotometry in optic nerve disease. Br J Ophthalmol 66:560-566 (1982).  PubMed

Braude LS, Cunha-Vaz JG, Goldberg MF, Frenkel M, Hughes JR. Diagnosing acute retrobular neritis by vitreous fluorophotometry. Am J Ophthalmol 91:764-773 (1981).  PubMed

Brooks AMV, Hussein CN, Chesterman JF, Martin JF, Alford FP, Penington DG. Platelets, coagulation and fibrinolysis in patients with diabetic retinopathy. Thromb Haemostas (Stuttgart) 49:123-127 (1983).  PubMed

Brooks AMV, Keith CG, Court JM, Hill MA. Vitreous fluorophotometry in children with type-I diabetes-mellitus. Aust J Ophthalmol 12:39-43 (1984).  PubMed

Bungay PM, Roy MS, Bonner RF. Posterior Vitreous Fluorophotometry: I. Description of a New Analysis Procedure and Results in Normal Subjects. Arch Ophthalmol:107:1321-1327 (1989).   PubMed

Bursell SE, Delori FC, Yoshida A, Parker JS, Collas GD,McMeel JW. Vitreous fluorophotometric evaluation of diabetics. Invest Ophthalmol Vis Sci 25:703-710 (1984).   PubMed

Buzney SM, Bartels SP, Macdonald SG, Frambach DA. An in vitro model of vascular leakage. Invest Ophthalmol Vis Sci 26(Suppl):171 (1985). 

Canning P, Kenny BA, Prise V, Glenn J, Sarker MH, Hudson N, Brandt M, Lopez FJ, Gale D, Luthert PJ, Adamson P, Turowski P, Stitt AW. Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes. Proc Natl Acad Sci U S A. 28:7213-8 (2016). PubMed

Cantrill HL, Pederson JE. Experimental retinal detachment III. Vitreous fluorophotometry. Arch Ophthalmol 100:1810-1813 (1982).  PubMed

Cantrill HL, Pederson JE. Experimental retinal detachment. VI. The permeability of the blood-retinal barrier. Arch Ophthalmol 102:747-751 (1984).  PubMed

Carmo A, Cunha-Vaz JG, Carvalho AP, Lopes MC. Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability. Nitric Oxide 4(6):590-6 (2000). PubMed

Carney M, Paylor R, Cunha-Vaz J, Jampol LM, Goldberg MF. Choroidal neovascularization in sickle cell patients. Invest Ophthalmol Vis Sci 26(Suppl):23 (1985).

Cellini M, Baldi A. Vitreous fluorophotometric recordings in HIV infection. Int Ophthalmol 15:37- (1991).  PubMed

Chahal P, Fallon TJ, Chowienczyk, Kohner EM. Quantitative changes in blood-retinal barrier function in central retinal vein occlusion. Trans Ophthalmol Soc U.K. 104:861-863 (1985).   PubMed

Chahal PS, Fallon, TJ, Kohner EM. Measurement of blood-retinal barrier function in central retinal vein occlusion. Arch Ophthalmol 104:554-557 (1986).  PubMed

Chaine G, Attali P, Gaudrie A, Colin MC, Quentel G, Coscas G. Ocular fluorophotometric and angiographic findings in toxemia of pregnancy. Arch Ophthalmol 104:1632-1635 (1986).   PubMed

Chase, PH, Jackson WE, Hoops SL, Cockerham RS, Archer PG, O’Brien D Glucose control and the renal and retinal complications of type I diabetes Draft. 

Chen CL, Cheng WS, Chen JL, Chiang CH. Potential of Nonoral a-Lipoic Acid Aqueous Formulations to Reduce Ocular Microvascular Complications in a Streptozotocin-Induced Diabetic Rat Model. J Ocul Pharmacol Ther.29(8):738-45 (2013).  PubMed

Chen S-C, Nakamura H, Tamura Z. Determination of fluorescein and fluorescein monoglucuronide excreted in urine. Chem Pharm Bull (Tokyo) 28:2812 (1980).  PubMed

Clarici J, Cavazos ET, Gartner J. Vitreous fluorophotometry using oral fluorescein. I. A new type of vitreous fluorophotometer (German). Klin Monatsbl Augenheilkd 183:511-514 (1983).  PubMed

Conway BP. An analysis of vitreous fluorophotometry. In: Retinal Diseases (S. I. Ryan, A. K. Dawson, H. L. Little eds). Grune and Stratton (Orlando) pp. 59-66 (1985). 

Conway BP. Technical variables in vitreous fluorophotometry. Graefe’s Arch Clin Exp Ophthalmol 222:194-201 (1985).  PubMed

Coscas G, Cunha-Vaz JG. Part 2: Chapter 25, Posterior segment fluorophotometry. Ophthalmology Today, p. 167.

Cunha-Vaz JG. A new perspective in diabetic retinopathy. In: New Directions In Ophthalmic Research edited by Dr. Marvin L. Sears. Yale University Press (New Haven & London) pp. 275-289 (1981). 

Cunha-Vaz JG. Blood-retinal barriers in health and disease. Trans Ophthalmol Soc U.K. 100:337-340 (1980).  PubMed

Cunha-Vaz JG. Desenvolvimento da fluorofotometria do vitreo. Actas IV Congresso Lus-Hispano-Brasileiro de Oftalmologia, Publisher. 2:351-355 (1980).

Cunha-Vaz JG. Diabetic retinopathy: Human and experimental studies. 111-124.  PubMed

Cunha-Vaz JG. Part 2, Chapter 26, What the future holds for ocular fluorophotometry? Ophthalmology Today, p. 173. 

Cunha-Vaz JG. Pathophysiology of diabetic retinopathy. Br J Ophthalmol 62:351-355 (1978).   PubMed

Cunha-Vaz JG. Protocols for the vitreous fluorophotometry examination: A general plan. Graefe’s Arch Clin Exp Ophthalmol 222: 220 (1985). 

Cunha-Vaz JG. Studies on the pathophysiology of diabetic retinopathy: the blood-retinal barrier in diabetes. Diabetes 32:20-26 (1983).  PubMed

Cunha-Vaz JG. Studies on the permeability of the blood-retinal barrier. Br J Ophthalmol 50:505-516 (1966).  PubMed

Cunha-Vaz JG. Studies on the permeability of the blood-retinal barrier. II. Breakdown of the blood-retinal barrier by injury. Br J Ophthalmol 50:454-462 (1966).  PubMed

Cunha-Vaz JG. The blood-ocular barriers. International Congress Series 508:14-27 (1978).

Cunha-Vaz JG. The blood-ocular barriers. Invest Ophthalmol Vis Sci 17:1037-1039 (1978).  

Cunha-Vaz JG. The blood-retinal barriers. Doc Ophthalmol 41:287-328 (1976).  PubMed

Cunha-Vaz JG. Vitreous fluorophotometry recordings in posterior segments disease. Graefe’s Arch Clin Exp Ophthalmol 222:241-247 (1985).  PubMed

Cunha-Vaz JG. Vitreous fluorophotometry studies in diabetes. Dev Ophthalmol 2:214-221 (1981).  PubMed

Cunha-Vaz JG. What the Future Holds for Ocular Fluorophotometry? In Book: Ophthalmology Today p. 173. 

Cunha-Vaz JG, De Lima JJP. Estimation of human retinal blood flow by slit lamp fluorophotometry. II. Results and discussion. Ircs Med Sci Biomed Techn (England) 3:11 (1975). 

Cunha-Vaz JG, Faria de Abreu JR, Campos AJ. Early breakdown of the blood-retinal barrier in diabetics. Br J Ophthalmol 59:649-656 (1975).  PubMed

Cunha-Vaz JG, Faria de Abreu JR, Teixeira R. The role of the retinal barrier. Excerpta Medica I.C.S. (Netherlands) 1:605-607 (1979). 

Cunha-Vaz JG, Fonseca JR, Faria de Abreu JR, Lima JJP. Studies on retinal blood flow II. Diabetic retinopathy. Arch Ophthalmol 96:809-811 (1978).  PubMed

Cunha-Vaz JG, Fonseca JR, Faria de Abreu JR, Ruas MA. A follow up study by vitreous fluorophotometry of early retinal involvement in diabetes. Am J Ophthalmol 86:467-473 (1978).  PubMed

Cunha-Vaz JG, Fonseca JR, Faria de Abreu JR, Ruas MA. Detection of early retinal changes in diabetes by vitreous fluorophotometry. Diabetes 28:16-19 (1979).  PubMed

Cunha-Vaz JG, Fonseca JR, Faria de Abreu JR. Vitreous fluorophotometry and retinal blood flow studies in diabetic retinopathy. Meth Pediat Ophthalmol 3:259-261 (1979). 

Cunha-Vaz JG, Fonseca JR, Faria de Abreu JR. Vitreous fluorophotometry and retinal blood flow studies in proliferative retinopathy. Albrecht V. Graefe’s Arch Klin Exp Ophthal 207:71-76 (1978).  PubMed

Cunha-Vaz JG, Fonseca JR, Hagenouw JRB. Treatment of early diabetic retinopathy with cyclandelate. Br J Ophthalmol 61:399-404 (1977).  PubMed

Cunha-Vaz JG, Goldberg MF, Vylantas C, Noth J. Early detection of retinal involvement in diabetes by vitreous fluorophotometry. Ophthalmology 86:264-275 (1979).  PubMed

Cunha-Vaz JG, Gray JR, Zeimer R, Mota MC, Ishimoto BM, Blair N, Leite E. Characterization of the early stages of diabetic retinopathy by vitreous fluorophotometry. Diabetes 34:53-59 (1985).  PubMed

Cunha-Vaz J, Leite E, Sousa JC, de Abreu JR. Blood-retinal barrier permeability and its relation to progression of retinopathy in patients with type 2 diabetes. A four-year follow-up study. Graefes Arch Clin Exp Ophthalmol 231(3):141-5 (1993). PubMed

Cunha-Vaz JG, Lima JP, Fonseca JR. (New methods of functional examination of the retina.) Exper Ophthalmol (Portugal) 4:1-7 (1978). 

Cunha-Vaz JG, Lima JP. Studies on retinal blood flow. Part I: Estimation of human retinal blood flow by slit lamp fluorophotometry. Arch Ophthalmol 96:893-897 (1978).  PubMed

Cunha-Vaz J, Lobo C, Sousa JC, Oliveiros B, Leite E, de Abreu JR. Progression of retinopathy and alteration of the blood-retinal barrier in patients with type 2 diabetes: a 7-year prospective follow-up study. Graefes Arch Clin Exp Ophthalmol 236:264-8 (1998).  PubMed

Cunha-Vaz JG, Mahlberg PA, Tessler HH. La fluorophotometrie du vitre dans le pars planite. Bull Mem Soc Fr Ophthalmol 94:345-349 (1982).  PubMed

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Cunha-Vaz JG, Maurice DM. The active transport of fluorescein by the retinal vessels and the retina. J Physiol 191:467-486 (1967).  PubMed

Cunha-Vaz JG, Mota C, Leite E, Faria de Abreu JR, Ruas MA. Effect of aldose-reductase inhibitors on the blood-retinal barrier in early diabetic retinopathy. Diabetes 34:109A (1985).  PubMed

Cunha-Vaz JG, Mota CC, Leite EC, Faria de Abreu JR, Ruas MA. Effect of sorbinil on blood-retinal barrier in early diabetic retinopathy. Diabetes 35:574-578 (1986).  PubMed

Cunha-Vaz JG, Mota CC, Leite EC, Faria de Abreu JR, Ruas MA. Effect of sulindac on the permeability of the blood-retinal barrier in early diabetic retinopathy. Arch Ophthalmol 103:1307-1311 (1985).  PubMed

Cunha-Vaz JG, Osborne NN, Chader GJ. Vitreous fluorophotometry In: Progress In Retinal Research (N. N. Osborne, G. J. Chader eds). Pergamon Press (Oxford) pp. 89-114 (1985).  

Cunha-Vaz JG, Rosenthal I, Weiss E, Blair N. Vitreous fluorophotometry and metabolic control in insulin-dependent juvenile-onset diabetic patients. Proceed 24th International Congress of Ophthalmology: 730-732 (1983). 

Cunha-Vaz JG, Travassos A. Breakdown of the blood-retinal barriers and cystoid macular edema. Surv Ophthalmol Suppl: 485-492 (1984).  PubMed

Cunha-Vaz JG, Tso MOM. The alteration of blood-retinal barriers in retinal disease and vitreous fluorophotometry. American Academy of Ophthalmology, Course 279 (1981). 

Cunha-Vaz JG, Zeimer R, Mahlberg P, Tessler H. Vitreous fluorophotometry studies in pars planitis. In: Retinal Diseases (S. I. Ryan, A. K. Dawson, H. L. Little eds). Grune and Stratton (Orlando) pp. 53-57 (1984). 

Cunha-Vaz JG, Zeimer R, Wong WP, Kiani R. Kinetic vitreous fluorophotometry in normals and noninsulin-dependent diabetics. Ophthalmology 89:751-756 (1982).  PubMed

Cunha-Vaz JG, Zeimer R. Configuration of the normal vitreous fluorophotometry. Graefe’s Arch Clin Exp Ophthalmol 222:234-236 (1985). 

Dacey DM. Dopamine-accumulating retinal neurons revealed by in vitro fluorescence display a unique morphology. Science 240:1196-1198 (1988).  PubMed

Dalgaard P, Barker VA, Lund-Anderson H. Vitreous fluorophotometry: Mathematical analysis of the effect of peripheral leakage on axial scans. Invest Ophthalmol Vis Sci 30:1522-1526 (1989).  PubMed

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Delori FC, Busell SE, Yoshida A, Mcmell JW. Vitreous fluorophotometry in diabetics: Study of artifactual contributions. Graefe’s Arch Clin Exp Ophthalmol 222:215-218 (1985).  PubMed

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Dickmann LJ, Yip V, Li C, Abundes J Jr, Maia M, Young C, Stainton S, Hass PE, Joseph SB, Prabhu S, Boswell CA. Evaluation of Fluorophotometry to Assess the Vitreal Pharmacokinetics of Protein Therapeutics. Invest Ophthalmol Vis Sci. 56(11):6991-9 (2015).  PubMed

Do Carmo A, Ramos P, Reis A, Proen R, Cunha-vaz JG.  Breakdown of the inner and outer blood retinal barrier in streptozotocin-induced diabetes.  Exp Eye Res 67:569-75 (1998).  PubMed

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Fishman GA, Cunha-Vaz JG, Salzano T. Vitreous fluorophotometry in patients with retinitis pigmentosa (draft). Arch Ophthalmol 99:1202-1207 (1981).  PubMed

Fishman GA, Cunha-Vaz JG, Travassos AC. Vitreous fluorophotometry in patients with fundus flavimaculatus. Arch Ophthalmol 100:1086-1088 (1982).  PubMed

Fishman GA, Cunha-Vaz JG. Carriers of X-linked recessive retinitis pigmentosa: Investigation by vitreous fluorophotometry. Int Ophthalmol 4:37-44 (1981). PubMed

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Frau E, Gregoire-Cassoux N, Offret M, Labetoulle M, Nodarian M, Lautier-Frau M, Offret H.  [Rupture of the hemato-ocular barrier, studied by fluorophotometry, in uveal melanoma patients. Preliminary results]  J Fr Ophtalmol 21:409-13.  (1998).  (French).  PubMed

Ghate D, Brooks W, McCarey BE, Edelhauser HF. Pharmacokinetics of intraocular drug delivery by periocular injections using ocular fluorophotometry. Invest Ophthalmol Vis Sci 48:2230-7 (2007). PubMed

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Iwase T, Oveson BC, Hashida N, Lima e Silva R, Shen J, Krauss AH, Gale DC, Adamson P, Campochiaro PA. Topical pazopanib blocks VEGF-induced vascular leakage and neovascularization in the mouse retina but is ineffective in the rabbit. Invest Ophthalmol Vis Sci 54(1):503-11 (2013).   PubMed

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