Increased permeability of the blood-aqueous barrier is considered to be a very sensitive measure of ocular inflammation. The Fluorotron has been used in clinical trials for many of the ocular preparations of non-steroidal anti-inflammatory drugs on the market today.
Selected References:
van Best J, del Castillo JB, Diestelhorst M, Heintz B, Leite E, Liesenborghs LF, Schalnus R. Diffusion coefficient through the blood-aqueous barrier using a standard protocol. Br J Ophthalmol 80:356-62 (1996). PubMed
Flach AJ, Graham J, Kruger LP, Stegman RC, Tanenbaum L. Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier following administration of 0.5% ketorolac tromethamine solution. Arch Ophthalmol 106:344-347 (1988). PubMed
Wu CC, Chang SW, Chen MS, Lee YT. Early change of vascular permeability in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol 15:529-33. (1995) PubMed